Spreading depolarization in acute brain injury inhibited by ketamine: a prospective, randomized, multiple crossover trial
نویسندگان
چکیده
منابع مشابه
Ketamine Associated Vomiting in Children Requiring Sedation: A Prospective Randomized Open Trial Study
Background In recent years, ketamine has been the most used sedative in Emergency Department (ED) procedures for pain management. Therefore, this study evaluated ketamine associated vomiting (KAV) in children requiring sedation. Materials and Methods This is a prospective, randomized, and open trial study carried out on children of ages 3 months to 13 years requiring sedation for medical diagn...
متن کاملCase Report Preliminary Evidence That Ketamine Inhibits Spreading Depolarizations in Acute Human Brain Injury
Background and Purpose—Spreading depolarizations, characterized by large propagating, slow potential changes, have been demonstrated with electrocorticography in patients with cerebral hemorrhage and ischemic stroke. Whereas spreading depolarizations are harmless under normal conditions in animals, they cause or augment damage in the ischemic brain. A fraction of spreading depolarizations is ab...
متن کاملPreliminary evidence that ketamine inhibits spreading depolarizations in acute human brain injury.
BACKGROUND AND PURPOSE Spreading depolarizations, characterized by large propagating, slow potential changes, have been demonstrated with electrocorticography in patients with cerebral hemorrhage and ischemic stroke. Whereas spreading depolarizations are harmless under normal conditions in animals, they cause or augment damage in the ischemic brain. A fraction of spreading depolarizations is ab...
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At the present, many drugs are used for inhibition of uterine contractions, but the proportions of preterm labors are increasing. Although magnesium sulfate is the most commonly prescribed parenteral tocolytic agent, but its optimal use has yet to be delineated. In this study a high-dose protocol for magnesium sulfate tocolytic therapy was compared with a low-dose regimen. One-hundred patie...
متن کاملAnalgesic Efficacy of Nephrostomy Tract inFiltration of Bupivacaine and Ketamine after Tubeless Percutaneous Nephrolithotomy: A Prospective Randomized Trial
Objectives:The aim of the present study was to assess the analgesic efficacy of IV ketamine injection inaddition to nephrostomy tract infiltration of ketamine – bupivacaine on postoperative pain relief after tubeless percutaneous nephrolithotomy (PCNL). Patients and Methods: Patients (n = 100), with renal stone who were candidates for PCNL were randomized to five groups with 20 cases in each: G...
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ژورنال
عنوان ژورنال: Journal of Neurosurgery
سال: 2019
ISSN: 0022-3085,1933-0693
DOI: 10.3171/2017.12.jns171665